Additions of Organomagnesium Halides to α‑Alkoxy Ketones: Revision of the Chelation-Control Model
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https://figshare.com/articles/dataset/Additions_of_Organomagnesium_Halides_to_Alkoxy_Ketones_Revision_of_the_Chelation-Control_Model/5107804
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资源简介：
The chelation-control
model explains the high diastereoselectivity
obtained in additions of organometallic nucleophiles to α-alkoxy
ketones but fails for reactions of allylmagnesium halides. Low diastereoselectivity
in ethereal solvents results from no chelation-induced rate acceleration.
Additions of allylmagnesium bromide to carbonyl compounds are diastereoselective
using CH2Cl2 as the solvent even though rate
acceleration is still absent. Stereoselectivity likely arises from
the predominance of the chelated form in solution. Therefore, a revised
chelation-control model is proposed.
创建时间：
2017-06-15
