Vitamin- D Supplementation with Moderate Exercise Enhance Plasma Insulin Levels in Prediabetes and Type 2 Diabetes Patients

The aim of the study is to investigate the relationship between the supplementation of vitamin -D with moderate exercise (ME) on plasma insulin level in Indian subjects of Pre and Type 2 diabetes mellitus. Several observational studies suggest that vitamin-D plays a role in the pathogenesis of pre and Type2 diabetes. We investigate the effect of ME with Vitamin-D supplementation in the pathogenesis of diabetes.&nbsp;Method:&nbsp;The Plasma Insulin and vitamin- D levels were measured using Radioimmunoassay and ELISA. We measured plasma Insulin level in the Indian subjects of age group (30-50 years) of N30, before and after vitamin- D supplementation with ME for the following groups. Vitamin- D deficient with Pre diabetes mellitus (PDM), vitamin -D deficient with Type 2 diabetes mellitus (T2DM), vitamin- D deficient with non-diabetes mellitus (NDM) and ME alone.&nbsp;Result:&nbsp;We observed that, plasma Insulin level were significantly (P&lt;0.05) increased after supplementation of vitamin- D with moderate exercise when compare to and ME alone.&nbsp;Conclusion:&nbsp;This study suggests that Vitamin- D supplementation with moderate exercise may improve insulin secretion from &beta; cells in Vitamin -D deficient with PDM and T2DM cases. &nbsp; &nbsp; &nbsp;本研究旨在探讨补充维生素D联合中等强度运动（moderate exercise, ME）对印度前驱糖尿病及2型糖尿病患者血浆胰岛素水平的影响。已有多项观察性研究表明，维生素D在前驱糖尿病与2型糖尿病的发病机制中发挥作用。本研究旨在探究维生素D联合中等强度运动对糖尿病发病机制的影响。 方法：采用放射免疫法与酶联免疫吸附试验（ELISA）分别检测血浆胰岛素与维生素D水平。本研究纳入年龄30~50岁的印度受试者共30例，分为以下四组，分别检测补充维生素D联合中等强度运动前后的血浆胰岛素水平：维生素D缺乏伴前驱糖尿病（PDM）组、维生素D缺乏伴2型糖尿病（T2DM）组、维生素D缺乏伴非糖尿病（NDM）组，以及单纯中等强度运动组。 结果：与单纯中等强度运动组相比，补充维生素D联合中等强度运动后，受试者血浆胰岛素水平显著升高（P<0.05）。 结论：本研究表明，对于维生素D缺乏的前驱糖尿病与2型糖尿病患者，补充维生素D联合中等强度运动可改善β细胞的胰岛素分泌功能。