HuR-dependent expression of Wisp1 is necessary for TGFbeta-induced cardiac myofibroblast activity

We show that activity of the RNA binding protein HuR is necessary for myofibroblast activation. This data set identifies directly bound HuR target genes in quiescent cardiac fibroblasts and active myofibroblasts. RNA-sequencing of eluted HuR-bound targets following photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in primary isolated murine cardiac fibroblasts treated with vehicle control or 10 ng/ml TGFbeta