Värmland Health Survey

A population-based health survey was carried out between 1962 and 1965 in the county of Värmland, Sweden. In total, 47,468 men and 48,079 women participated (mean age 48.7 years, range 22-99 years). The screening consisted of measurement of height (m), weight (kg) and blood pressure (BP; mmHg), as well as blood sampling including the determination of serum SA concentration (mg/L). All subjects have been followed in national registers until end of 2005 for in-hospital registered diagnosis. the cohort is also linked with data from the Swedish population and housing census in 1960. Purpose: The Swedish National Board of Health decided in 1961 to undertake a general health survey in the county of Värmland and also in parts of the county of Gävleborg in Sweden, the so called Värmland Health Survey (VHS). The survey was conducted between 1962 and 1965 in connection with the mass-screening programme of miniature photo fluorography (x-ray) of the chest. The aim of the survey was to perform a chemical mass-screening to identify pre-symptomatic disease, especially different types of CVD, malignancies and inflammatory conditions. Improved laboratory techniques and automated laboratory methods were used for screening. Simple measurements of some physical variables were also performed. The examination included a questionnaire with questions on previous hypertension, albuminuria, diabetes and anaemia or any infection during the previous three weeks. No information on diet, smoking habits, alcohol consumption or number of pregnancies was collected. In three districts of Värmland (Arvika, Hagfors and Karlstad) and in one district of Gävleborg, (Hofors-Torsåker), inhabitants 25 years of age or older were invited to participate in the survey. Despite the age limit, a small number of individuals younger than 25 years of age also participated. All together 97,273 subjects underwent the screening, (~76% attendance in Värmland and 86% in Gästrikland). The large amount of data collected has previously been described and used in three different projects for studying the role of sialic acid in prediction of CVD by Lindberg et a.l and Khalili et. al. The role of cholesterol in prediction of cancer has been studied by Törnberg et al..1962年至1965年间，瑞典韦姆兰郡（Värmland）开展了一项基于人群的健康调查（population-based health survey）。共计47468名男性与48079名女性参与本次研究，参与者平均年龄为48.7岁，年龄跨度为22至99岁。本次筛查包含身高（米，m）、体重（千克，kg）与血压（blood pressure, BP；毫米汞柱，mmHg）的测量，以及血液采样环节，其中涵盖血清唾液酸（sialic acid, SA；毫克每升，mg/L）浓度的测定。所有受试者均被纳入国家登记系统进行随访，直至2005年底，以获取住院登记的诊断信息。该研究队列还与1960年瑞典人口与住房普查数据完成了关联匹配。 研究目的： 瑞典国家卫生委员会于1961年决定在瑞典韦姆兰郡及耶夫勒堡郡（Gävleborg）部分区域开展全民健康调查，即韦姆兰健康调查（Värmland Health Survey, VHS）。 本次调查于1962年至1965年间开展，与胸部微型荧光摄影（X线）大规模筛查项目同步进行。调查的核心目标为通过化学物质大规模筛查，识别症状前疾病，尤其是各类心血管疾病（cardiovascular disease, CVD）、恶性肿瘤与炎症性疾病。本次筛查采用了改良的实验室技术与自动化检测方法，同时完成了部分生理指标的简易测量。检查内容还包含一份问卷，用于收集既往高血压、蛋白尿、糖尿病、贫血病史，以及过去三周内是否存在感染相关信息。研究未采集饮食、吸烟习惯、饮酒量或妊娠次数相关数据。 本次调查面向韦姆兰郡的阿尔维卡（Arvika）、哈格福什（Hagfors）、卡尔斯塔德（Karlstad）三个行政区，以及耶夫勒堡郡的霍福斯-托瑟克（Hofors-Torsåker）行政区内25岁及以上的居民招募参与者。尽管设有年龄上限，仍有少量25岁以下的个体参与了本次调查。总计共有97273名受试者接受了筛查，韦姆兰郡的参与率约为76%，耶夫勒堡地区（Gästrikland）的参与率为86%。 本次研究收集的海量数据此前已被林德伯格（Lindberg）等人与哈利利（Khalili）等人用于三项不同的研究，以探讨唾液酸在心血管疾病预测中的作用；托尔恩贝里（Törnberg）等人则针对胆固醇在癌症预测中的作用开展了相关研究。