Sensitivity of polymerase chain reaction (PCR), Kato-Katz (KK), up-converting particle circulating anodic antigen (UCP-LF CAA), and point-of-care circulating cathodic antigen (POC-CCA) compared to a composite reference standard (CRS) over time.

Data shown for the standard group (n = 56) who received a single PZQ treatment at week 0 and the intense treatment group (n = 69) who received four repeated PZQ treatments at weeks 0, 2, 4, and 6. The composite reference standard (CRS) was based on KK, PCR, and UCP-LF CAA: an individual was considered positive if at least one of these tests was positive (i.e., test specificity assumed to be 100%).