five

A single-cell map of hypertension

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP593167
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We established a single-cell map of hypertension and hypertensive injury across five key organs: hypothalamus, kidney, heart, 3rd order mesenteric artery, and middle cerebral artery. We analyzed three widely used models of hypertension: angiotensin II-treated mice, salt-sensitive rats and spontaneously hypertensive rats. We generated 612,984 single-nucleus RNA-seq profiles, 179,637 single-nucleus ATAC-seq profiles, and spatial transcriptome data, providing a multi-model, multi-tissue resource for dissecting the molecular and cellular changes in hypertension.
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2025-08-13
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