The Ras-family small GTPase RAB25 is involved in numerous aspects of endosomal protein trafficking and cell polarity. Recent evidence has established a role for RAB25, as well as related RAB-family an
Despite over 50 oncogenic RAS mutations, specific mutations track with distinct cancer types. To elucidate the underlying contribution of oncogenic signaling to RAS mutation patterns we globally acti
Crystal Structure of SHOC2 to a resolution of 2.4 Angstrom Descriptor: CHLORIDE ION, Leucine-rich repeat protein SHOC-2, SULFATE ION Authors: Bonsor, D.A, Simanshu, D.K. Deposit date: 2022-02-04 Relea
Oncogenic Ha-Ras is a potent inhibitor of skeletal muscle cell differentiation, yet the Ras effector mediating this process remains unidentified. Here we demonstrate that the atypical protein kinases