A Retrospective Observational Assessment of the Factors Related to Poor Prognosis and Overall Survival Rates in Patients Diagnosed with Laryngeal Squamous Carcinoma

AbstractAim: The aim of the study was to factors related to poor prognosis and overall survival ratesin patients diagnosed with laryngeal squamous carcinoma.Methods: The present study was conducted in the Department of ENT, SKMCH,Muzaffarpur, Bihar, India for the period of 1 year. 100 patients were included in the study.Results: Age and denial of care were the factors related to patient delay, medical doctors, thefirst consult decision and the malpractice were statistically related to the professional delay.The mean of patient delay was 62.46 weeks and thought there was a difference betweendifferent groups of patient, the latest was not statistically significant. Same goes for theprofessional delay where the mean delay was 15.70 weeks.Conclusion: The TNM system is an anatomical means of classification, which takes intoaccount neither the biological aggressiveness of the specific tumor nor the host'simmunological response. It was not developed to serve as a specific guideline for themanagement of a particular patient, nor does the system have the ability to predict theoutcome of individual patients. Whereas physicians are focused on the concept of optimaltreatment, patients are interested in their prognosis, and one of the most important tasks is toassess our present ability to predict the probable outcome for an individual patient withlaryngeal cancer.摘要 研究目的：本研究旨在明确喉鳞状细胞癌患者不良预后与总体生存率的相关影响因素。 研究方法：本研究于印度比哈尔邦穆扎法尔布尔的SKMCH耳鼻喉科（Ear, Nose and Throat, ENT）开展，研究周期为1年，共纳入100例入组患者。 研究结果：年龄与就医拒绝是导致患者诊疗延误的相关因素；首诊医师、首诊决策及诊疗失误与专业诊疗延误存在统计学关联。患者诊疗延误的平均时长为62.46周，尽管不同患者亚组间存在差异，但该差异无统计学意义。专业诊疗延误的平均时长为15.70周，结果同理。 研究结论：TNM分期系统（TNM staging system）属于解剖学分类工具，既未考量特定肿瘤的生物学侵袭性，也未纳入宿主的免疫应答状态。该系统并非为特定患者的个体化诊疗管理制定专属指南，亦无法预测个体患者的临床转归。临床医师侧重于优化治疗方案的制定，而患者更关注自身预后情况，当前一项核心任务便是评估现有技术能力，以精准预测个体喉癌患者的潜在临床转归。