Additional file 4: of Global identification of hnRNP A1 binding sites for SSO-based splicing modulation

Lists of hnRNP A1 iCLIP binding peaks, hnRNP A1 iCLIP binding peaks in cassette exons including 50 bp in flanking introns, and gene expression and exon usage changes after hnRNP A1 knockdown in HeLa cells (FDR <0.1). In addition, a list of the genes with hnRNP A1 binding peaks in cassette exons including 50 bp in flanking introns present in the Orphanet, ClinVar (Pathogenic LoF), or Developmental Disorders (DDG2P) databases (NCBI). The complete output from the RNA sequencing and iCLIP analysis can be found in the ArrayExpress database ( https://www.ebi.ac.uk/arrayexpress/ ) under accession number E-MTAB-3612. (XLSX 2197 kb)

本数据集包含以下内容：异质性核核糖核蛋白A1（hnRNP A1）的iCLIP结合峰列表、包含侧翼内含子50bp序列的盒式外显子（cassette exon）区域内的hnRNP A1 iCLIP结合峰列表，以及海拉细胞（HeLa）中hnRNP A1基因敲低后的基因表达与外显子使用变化数据（错误发现率FDR<0.1）。此外，本数据集还包含经美国国家生物技术信息中心（National Center for Biotechnology Information，NCBI）注释的基因列表：此类基因在包含侧翼内含子50bp序列的盒式外显子区域带有hnRNP A1结合峰，且相关基因收录于Orphanet、ClinVar（致病性功能丧失变异）或发育障碍基因2项目（Developmental Disorders Gene 2 Project，DDG2P）数据库。RNA测序与iCLIP分析的完整输出结果可在ArrayExpress数据库（https://www.ebi.ac.uk/arrayexpress/）的登录号E-MTAB-3612项下获取，本数据集文件格式为XLSX，大小为2197 kb。