Additional file 1 of Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders

Additional file 1: Table S1. Definition of the cases and the controls in FinnGen. Table S2. Download link for GWAS data. Table S3. Information on instrumental variables for the causal effect of chronic liver diseases on musculoskeletal disorders. Table S4. Detailed information on instrumental variables for the causal effect of chronic liver diseases on osteoporosis. Table S5. Detailed information on instrumental variables for the causal effect of chronic liver diseases on osteoarthritis. Table S6. Detailed information on instrumental variables for the causal effect of chronic liver diseases on sarcopenia. Table S7. Information on instrumental variables for the causal effect of musculoskeletal disorders on chronic liver diseases. Table S8. Detailed information on instrumental variables for the causal effect of osteoporosis on chronic liver diseases. Table S9. Detailed information on instrumental variables for the causal effect of osteoarthritis on chronic liver diseases. Table S10. Detailed information on instrumental variables for the causal effect of sarcopenia on chronic liver diseases. Table S11. Steiger filtering results. Table S12. Excluded outlier SNPs. Table S13. Results of CAUSE method. Table S14. Mendelian randomization analysis of the causal effect of osteoporosis on chronic liver diseases. Table S15. Mendelian randomization analysis of the causal effect of osteoarthritis on chronic liver diseases. Table S16. Mendelian randomization analysis of the causal effect of sarcopenia on chronic liver diseases. Table S17. Heterogeneity and pleiotropy test of forward Mendelian randomization studies. Table S18. Heterogeneity and pleiotropy test of reverse Mendelian randomization studies. Table S19. Results of latent causal variable model.

附加文件1：表S1。芬兰基因研究（FinnGen）中病例组与对照组的定义。
表S2。全基因组关联研究（Genome-Wide Association Study, GWAS）数据下载链接。
表S3。慢性肝病（chronic liver diseases）对肌肉骨骼疾病（musculoskeletal disorders）因果效应的工具变量相关信息。
表S4。慢性肝病对骨质疏松症（osteoporosis）因果效应的工具变量详细信息。
表S5。慢性肝病对骨关节炎（osteoarthritis）因果效应的工具变量详细信息。
表S6。慢性肝病对肌肉减少症（sarcopenia）因果效应的工具变量详细信息。
表S7。肌肉骨骼疾病对慢性肝病因果效应的工具变量相关信息。
表S8。骨质疏松症对慢性肝病因果效应的工具变量详细信息。
表S9。骨关节炎对慢性肝病因果效应的工具变量详细信息。
表S10。肌肉减少症对慢性肝病因果效应的工具变量详细信息。
表S11。Steiger过滤检验结果。
表S12。已剔除的异常单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）。
表S13。CAUSE方法分析结果。
表S14。骨质疏松症对慢性肝病因果效应的孟德尔随机化（Mendelian randomization）分析结果。
表S15。骨关节炎对慢性肝病因果效应的孟德尔随机化分析结果。
表S16。肌肉减少症对慢性肝病因果效应的孟德尔随机化分析结果。
表S17。正向孟德尔随机化研究的异质性与多效性检验结果。
表S18。反向孟德尔随机化研究的异质性与多效性检验结果。
表S19。潜在因果变量模型分析结果。