MOESM8 of Global impact of somatic structural variation on the DNA methylome of human cancers

Additional file 8. Related to Fig. 5. SSV associations with disruption of TADs. All SSVs involving TAD disruption (i.e. SSVs with breakpoints spanning TAD boundaries), as well as the subset of SSVs with breakpoints located in proximity to a gene (0-100â kb upstream, 0-100â kb downstream, or within the gene body) and associated with altered expression or methylation, are included.

补充文件8：与图5相关。本文件收录与拓扑关联结构域（Topologically Associating Domain，TAD）断裂相关的体细胞结构变异（Somatic Structural Variant，SSV）关联数据。具体而言，本文纳入所有涉及TAD断裂的SSV（即断点跨越TAD边界的SSV），同时纳入一类SSV子集：其断点位于基因邻近区域（基因上游0-100 kb、下游0-100 kb或基因本体内部），且与基因表达或甲基化水平改变相关。