BALF - raw

This dataset was generated in an in vivo OECD TG 413 90-days nose-only inhalation study where Sprague Dawley rats were exposed of either aerosols of the mentholated version of the tobacco heating system 2.2 (THS2.2M) or smoke of 2 two mentholated reference cigarettes (MRC(LM) and MRC(HM)) in comparison with 3R4F cigarette smoke. Free lung cells (FLCs) in the bronchoalveolar lavage fluid were characterized and quantified by flow cytometry and BALF was characterized using targeted proteomics.
This dataset includes single measurements for each animal.

本数据集源自一项遵循经济合作与发展组织（OECD）试验指南413（TG 413）的90天鼻吸入暴露体内研究：实验为斯普拉格-道利大鼠（Sprague Dawley rats）分别暴露烟草加热系统2.2薄荷醇版本（tobacco heating system 2.2 (THS2.2M)）的气溶胶、2款薄荷醇参比卷烟（MRC(LM)与MRC(HM)）的烟气，并以3R4F卷烟烟气作为对照。研究通过流式细胞术对支气管肺泡灌洗液（bronchoalveolar lavage fluid, BALF）中的游离肺细胞（free lung cells, FLCs）进行表征与定量，并采用靶向蛋白质组学技术对BALF开展表征分析。本数据集包含每只实验动物的单次测量数据。