Metadata record for the article: High Prevalence of APOA1/C3/A4/A5 Alterations in Luminal Breast Cancers among Young Women in East Asia

Summary

This
metadata record provides details of the data supporting the claims of the
related article: “High Prevalence of APOA1/C3/A4/A5
Alterations in Luminal Breast Cancers among Young Women in East Asia”.

The
related study aimed to identify unique genetic alterations in emerging tumours distinctly
characterised by a high prevalence of estrogen receptor (ER)–positive/human
epidermal growth factor receptor (HER2)–negative cancer, for which the incidence
rate among women aged <50 years in East Asia has rapidly increased.

Type of data:
copy number variations (CNVs); clinical data

Subject of
data: Homo sapiens

Patient
characteristics & recruitment: patients with breast cancer diagnosed
between April 2009 and July 2011 at National Taiwan
University Hospital (NTUH), Taiwan. The clinicopathological information
of these patients was obtained from electronic medical record.

Data
access

The CNV
dataset of the 120 breast tumours in the NTUH discovery cohort has been
deposited in the Gene Expression Omnibus (GEO) under accession https://identifiers.org/geo:GSE80526.

The Metabric
dataset is available in the European
Nucleotide Archive under accession https://identifiers.org/ena.embl:EGAD00010000164.

The breast
cancer gene expression datasets used for comparison between East Asian and
Western women are available in GEO under accessions: https://identifiers.org/geo:GSE20685,
https://identifiers.org/geo:GSE21653,
https://identifiers.org/geo:GSE23720,
https://identifiers.org/geo:GSE20194,
https://identifiers.org/geo:GSE45255.

Clinical data in the files ‘NTUH
discovery cohort patient data.xlsx’ and ‘NTUH validation cohort patient
data.xlsx’ are not publicly available as they contain
information that could compromise research participant privacy and informed
consent to share participant-level data was not obtained prior to or during
data collection. Requests for these data should be directed to Dr. Lin CH with
data requests.

The file ‘TagMan Copy Number Assay data.xlsx’ is
openly available with this data record.

Corresponding author(s) for this study

Chiun-Sheng
Huang, National Taiwan University Hospital, No 7, Chung-Shan South Rd, Taipei
10016, Taiwan. Phone: [phone] ext. 65080; Fax: [phone]; Email: [e-mail].

Ching-Hung
Lin, Department of Oncology, National Taiwan University Hospital, Taipei,
Taiwan. [e-mail].

Study
approval

The
study’s protocol was approved by the ethics committee of NTUH (200902014R).