Supplemental tables for the V/J allele analysis of Mabs

This folder contains two supplementary table for the manuscript “The immunogenicity of human-origin therapeutic antibodies are associated with V gene usage”. Supplementary Table 1: A table containing the median percent of sequences that contain a V or J gene in the B cell repertoire sequencing dataset from OAS. Supplementary Table 2: A table containing the information of 93 human or humanized antibody drugs, including the clinical ADA rate, the usage of V and J alleles, the number of mismatches with the germline, the disease indications, the antibody type (human or humanized) and first US approval time.

本文件夹收录了学术论文《人源治疗性抗体的免疫原性与V基因使用偏好相关》的两张补充表格。补充表1：收录了来自OAS的B细胞受体组测序数据集中，包含V或J基因的序列的中位数占比相关表格。补充表2：收录了93种人源或人源化抗体药物的相关信息，具体包括临床ADA（Anti-Drug Antibody）阳性率、V和J等位基因使用情况、与生殖系序列的错配数量、疾病适应症、抗体类型（人源或人源化）以及美国首次获批时间。