Additional file 1: of Synchronous birth is a dominant pattern in receptor-ligand evolution

Page 1 1: Branch of appearance of each of the 19,928 human genes. 2: Branch of appearance of the 1000 genes of bilaterians drawn randomly. Page 2: Branch of appearance of human genes for the mathematical model. Page 3: Branches of appearance of ligands and receptors. Page 4: List of receptor/ligand interactions. The file contains the interactions present in our database, as well as the interactions present in the list of Ramilowski et al., 2015. Page 5: List of ligands that have evolved rapidly. Page 6: List of characteristics of ligands and receptors used for MCA. The characteristics are the molecular weight before and after cleavage, the synthesis, the groups 1 to 9 according to the characteristics of the proteins (ex glycoproteins), the type of signal and the function of the interaction. (XLSX 578 kb)

第1页：1. 19928个人类基因各自的演化出现分支；2. 随机选取的1000个两侧对称动物基因的演化出现分支。
第2页：用于数学模型的人类基因演化出现分支。
第3页：配体（ligand）与受体（receptor）的演化出现分支。
第4页：受体/配体相互作用列表。该文件收录了本研究数据库中的相互作用，以及Ramilowski等人2015年发表的文献列表中的相互作用。
第5页：进化速率较快的配体列表。
第6页：用于多重对应分析（Multiple Correspondence Analysis, MCA）的配体与受体特征列表。所列特征包括：切割前后的分子量、合成特性、依据蛋白质特性划分的1至9类组别（例如糖蛋白）、信号类型以及相互作用的功能。（XLSX 578 KB）