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Memory CD8+ T cells require stress-levels of acetate for optimal function. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA316377
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How systemic metabolic alterations during acute infections impact immune-cell function remains poorly understood. Hess and colleagues demonstrate that acetate rapidly increases during infections, which drives acetylation of GAPDH in memory CD8+ T cells and thereby catalyzes the rapid recall response. Overall design: Comparison of mRNA profile of control vs. 3d acetate exposed memory OT-I T cells
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2016-03-25
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