Generation of functional ciliated cholangiocytes from human pluripotent stem
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE175502
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We report on the successful generation of functional ciliated cholangoocytes from hPSCs that will provide new opportunities to study and treat diseases of the liver. Both monolayer- and organoid-derived cells are adaptable for further bioengineering approcahes to produce more complex hPSC-deived liver tissue with biliary ductal structures. Additionally, the successful engraftment of differentiated cholangiocytes in the liver of immune-imcompetent mice provides the basis for developing novel therapeutic strategies to treat cholangiopathies. Examination of heterogeneity and global transcriptome between 2D and 3D cholangiocytes
创建时间：
2021-12-02
