DATASET of the publication "Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites"

High-grade serous ovarian carcinoma (HGSOC) is one of the deadliest malignancies in female population. The fluid accumulation in the peritoneal cavity, or ascites, is a peculiar pathological sign during late stages. Malignant cells are often a minority population in ascites making the detection and analysis of cancer cells a challenge. Here we submit the dataset of the pubblication “Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites”, where combinatorial approach for the detection of malignant cells in OC ascites based on TP53 deep sequencing and PAX8 cytological staining was performed. Among other, dataset contains PAX8 staining images used for quantification and Sanger sequences relative to the publication.

高级别浆液性卵巢癌（High-grade serous ovarian carcinoma, HGSOC）是女性人群中致死率最高的恶性肿瘤之一。腹腔积液（ascites，又称腹水）是该病晚期阶段的特征性病理性体征。腹水中的恶性细胞通常仅占少数群体，这使得癌细胞的检测与分析面临极大挑战。本研究提交了发表于论文《免疫磁珠富集联合PAX8/TP53分子病理学方法可提升腹水中卵巢癌细胞的检测灵敏度》的数据集，该数据集涵盖了本研究中采用的基于TP53深度测序与PAX8细胞学染色的卵巢癌腹水中恶性细胞检测联合方案的相关数据。除此之外，本数据集还包含用于定量分析的PAX8染色图像，以及与该研究相关的Sanger测序（Sanger sequencing）序列。