A Virtual Cohort of Twenty-four Left-ventricular Models of Ischemic Cardiomyopathy Patients

Motivation: Computational models of the heart are increasingly being used in the development of devices, patient diagnosis and therapy guidance. While software techniques have been developed for simulating single hearts, there remain significant challenges in simulating cohorts of virtual hearts from multiple patients. Dataset Description: We present the first database of left-ventricular (LV) models suitable for electrophysiology simulations. Our database consists of twenty-four LV models including infarct scar morphology. These were generated from LGE-MRI acquired from ICM patients undergoing CRT. We used 24 image-based patient-specific models of LV anatomy and scar morphology. Briefly, LV endocardium and epicardium contours were manually drawn in each short-axis slice of LGE-MRI. Scar and BZ were segmented and reconstructed in 3D. A finite element tetrahedral mesh (mean edge length of 0.8mm) was generated and 3D reconstructed scar and BZ segmentations were mapped onto it. Rule-based fibres were assigned to the models. The elements of all the twenty-four meshes are labelled as follows: 1) Left ventricular myocardium 3) Scar core 4) Scar border zone We defined a system of universal ventricular coordinates on the meshes: an apico-basal coordinate varying continuously from 0 at the apex to 1 at the base; a transmural coordinate varying continuously from 0 at the endocardium to 1 at the epicardium; a rotational coordinate varying continuously from – π at the left ventricular free wall, 0 at the septum and then back to + π at the left ventricular free wall. We built the first cohort of twenty-four LV meshes from ICM patients LGE-MRI data. These geometries can be used for large cohort computational studies.

研究背景：心脏计算模型在器械研发、患者诊断与治疗指导中的应用日益广泛。尽管目前已开发出针对单心脏仿真的软件技术，但从多名患者中构建虚拟心脏队列并开展仿真仍面临诸多重大挑战。
数据集说明：本研究首次发布适用于电生理仿真的左心室（Left Ventricular, LV）模型数据库。该数据库包含24例涵盖梗死瘢痕形态的LV模型，均源自接受心脏再同步治疗（Cardiac Resynchronization Therapy, CRT）的缺血性心肌病（Ischemic Cardiomyopathy, ICM）患者的钆延迟增强磁共振成像（Late Gadolinium Enhancement-MRI, LGE-MRI）数据，我们基于该影像数据构建了24例患者特异性的LV解剖结构与瘢痕形态模型。具体而言，我们在每一幅LGE-MRI短轴切片中手动勾画LV心内膜与心外膜轮廓，对瘢痕组织与边界带（Border Zone, BZ）进行分割并完成三维重建；生成平均边长为0.8mm的有限元四面体网格，并将三维重建的瘢痕与BZ分割结果映射至该网格；随后为模型分配基于规则的心肌纤维分布。所有24个网格的单元标签分类如下：1）左心室心肌；3）瘢痕核心；4）瘢痕边界带。我们还为所有网格定义了一套通用心室坐标系统：一是心尖-心底坐标，从心尖处的0连续变化至心底处的1；二是透壁坐标，从心内膜处的0连续变化至心外膜处的1；三是旋转坐标，从左心室游离壁处的-π、室间隔处的0，再回到左心室游离壁处的+π。本研究基于ICM患者的LGE-MRI数据构建了首个包含24例LV网格的队列，这些几何模型可用于大规模队列计算研究。