Supplementary data.xlsx

This study aimed to utilize two publicly available datasets (ProteomeXchange Consortium, Dataset Identifier: PXD043352; Gene Expression Omnibus, GEO: GSE67539) to explore potential age-dependent regulation of presumptive NeuroD2 target genes. Genome-wide NeuroD2 target sequences were filtered and analyzed for potential age-related changes. This approach aimed to shed light on the hypothetical role of NeuroD2 in age-related molecular mechanisms in the hippocampus.

本研究旨在利用两套公开可用的数据集（蛋白质组交换联盟（ProteomeXchange Consortium），数据集标识符：PXD043352；基因表达综合数据库（Gene Expression Omnibus，GEO）：GSE67539），探究推定的神经分化因子2（NeuroD2）靶基因的年龄依赖性调控规律。研究人员对全基因组范围内的NeuroD2靶标序列进行筛选，并分析其潜在的年龄相关变化。本分析策略旨在阐明神经分化因子2在海马体年龄相关分子机制中的潜在作用。