Neuron Morphology data in .swc format from Patch-seq experiments in human neocortex, Cell ID 759960718

Human neocortical neurons display diverse morphology, physiology and gene expression profiles. We use a method called Patch-seq, where these three data modalities are assayed simultaneously from the same neuron, to understand how the genetic profile of human neocortical neuron types corresponds to their morphological and electrophysiological phenotypes. This collection may contain image stacks (TIFF), reconstruction files in image space (.swc, µm), a transformed file (.swc, µm) oriented so that the y axis extends vertically towards the pia surface, and a marker file (.marker, µm) indicating nodes where dendrites were truncated (10), reconstruction was not continued (20), or surface of tissue was closest to soma (30).

人类大脑新皮层神经元具有多样的形态学、生理学及基因表达谱特征。我们采用一种名为Patch-seq的技术，可从同一神经元中同时获取三类数据模态的检测结果，以此解析人类新皮层神经元类型的基因特征与其形态学、电生理学表型之间的对应关系。本数据集可包含图像堆栈（TIFF格式）、图像空间重建文件（.swc，单位：微米）、经坐标转换的.swc格式文件（单位：微米，其y轴垂直朝向软脑膜表面），以及标记文件（.marker，单位：微米）。该标记文件用于标注三类节点：树突被截断的节点（编码值10）、未继续进行重建的节点（编码值20），以及距胞体最近的组织表面节点（编码值30）。