Increased YAP transcriptional activity in in male murine steroidogenic zG adrenocortical cells

To specifically evaluate the effect of an increase of the transcriptional activity of YAP in mice adrenal gland we generated a mouse mode expressing a constitutively active form of human YAP (YAP5SA) in aldosterone-producing zG cells. RNAseq analysis on whole adrenal glands were performed on one month male mice RNAseq gene expression profile for WT (Rosa26YAP5SA/+) and mutant mice adrenal glands (Rosa26YAP5SA/+; AScre/+) (n=3/group)