HRH1

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

组胺作为一种广泛分布的信使分子，源自肥大细胞、肠嗜铬样细胞及神经元。其多样化的生理效应由组胺受体H1、H2、H3和H4介导。本基因编码的蛋白质为跨膜蛋白，属于G蛋白偶联受体超家族。它参与调节平滑肌的收缩、由于终末静脉收缩引起的毛细血管通透性增加、肾上腺髓质中儿茶酚胺的释放以及中枢神经系统的神经传递。组胺与多种生理过程相关，包括记忆与学习、昼夜节律以及体温调节。此外，组胺亦与多种过敏性疾病的病理生理学相关，如特应性皮炎、哮喘、过敏性休克和过敏性鼻炎。已鉴定出多种选择性剪接变体，它们编码同一种蛋白质。[由RefSeq提供，2015年1月]