Antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers in the Thames catchment

This dataset contains the concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, oseltamivir carboxylate, measured at 21 locations within the River Thames catchment in England. The measurements were taken weekly during November 2009, once in March 2010 and once in May 2011, with the aim to quantify pharmaceutical usage during the influenza pandemic of 2009 and how this compares to inter-pandemic drug use. River samples were acquired by grab samples in glass jars and analysed by liquid chromatography tandem mass spectrometry (LC MS). Two wastewater treatment plants (WWTPs) in southern England (Benson and Oxford) were also sampled during the peak of the second wave of the 2009 influenza A[H1N1]pdm09 pandemic (10-11 November 2009) and on 15 May 2011 using an automated sampler set to acquired hourly (time proportional) samples from the influent and effluent of the WWTPs. The WWTPs are the source for all the drugs found in the river, hence, these were studied to understand the differential fate of the analytes in the two very different WWTPs. Flows for the WWTP and River sampling locations are presented for each of the sampling times to allow for determining hourly loads for the WWTP and daily loads for the river.

本数据集包含11种抗生素（甲氧苄啶、土霉素、环丙沙星、阿奇霉素、头孢噻肟、多西环素、磺胺甲恶唑、红霉素、克拉霉素、氧氟沙星、诺氟沙星）、3种减充血剂（萘甲唑啉、羟甲唑啉、赛洛唑啉）以及抗病毒药物奥司他韦的活性代谢产物奥司他韦羧酸的浓度数据，采样覆盖英格兰泰晤士河流域的21个监测点位。采样工作于2009年11月期间每周开展1次，另分别于2010年3月和2011年5月各完成1次采样，旨在量化2009年流感大流行期间的药物使用情况，并对比其与大流行间期的药物使用模式。河流样本采用玻璃罐瞬时采样法获取，并通过液相色谱-串联质谱（liquid chromatography tandem mass spectrometry, LC-MS）进行分析。英格兰南部的两座污水处理厂（wastewater treatment plant, WWTP）：Benson厂与Oxford厂，也在2009年甲型H1N1流感大流行（A[H1N1]pdm09）第二波疫情峰值时段（2009年11月10日至11日）及2011年5月15日开展了采样，采用自动采样器对两座厂的进水与出水进行每小时按时间比例采样。这两座污水处理厂是河流中检出所有目标药物的来源，因此本研究对其开展监测，以解析不同目标分析物在两座工艺特征差异显著的污水处理厂中的归趋差异。本数据集同时提供了各采样时段内污水处理厂与河流监测点位的流量数据，以便计算污水处理厂的小时药物负荷与河流的日药物负荷。