Cure Glomerulonephropathy

Glomerular diseases are chronic diseases that cause damage to the filters, glomeruli, in the kidneys. Damaged glomeruli allow red blood cells and protein to leak into the urine, cause waste products to build up in the blood, and can lead to kidney failure. Glomerular diseases affect individuals of all ages and tend to progress slowly in many patients. Due to lengthy follow-up periods and challenges with patient recruitment, previous efforts to study glomerular diseases have been difficult.

Cure Glomerulonephropathy Network (CureGN) is a multi-center consortium that seeks to establish an infrastructure for the advancement of glomerular disease studies. CureGN recruits and maintains a large and diverse population of glomerular disease patients. The study established a database of patients diagnosed with the following conditions: minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and immunoglobulin A nephropathy (IgAN).

Currently, data from one analysis dataset is available for request.

肾小球疾病是一类会损伤肾脏滤过单元——肾小球（glomeruli）的慢性疾病。受损的肾小球可使红细胞与蛋白质漏入尿液，导致代谢废物在血液中蓄积，最终引发肾衰竭。该病可发生于各年龄段人群，多数患者的病情进展较为缓慢。由于随访周期漫长且患者招募存在诸多困难，既往肾小球疾病相关研究的推进面临诸多阻碍。

治愈肾小球病网络（Cure Glomerulonephropathy Network, CureGN）是一个多中心联盟，旨在构建推动肾小球疾病研究发展的基础设施。该联盟招募并维护了一个规模庞大、队列构成多样的肾小球疾病患者群体。本研究建立了涵盖以下四类确诊患者的数据库：微小病变肾病（minimal change disease, MCD）、局灶节段性肾小球硬化症（focal segmental glomerulosclerosis, FSGS）、膜性肾病（membranous nephropathy, MN）以及IgA肾病（immunoglobulin A nephropathy, IgAN）。

目前，一份分析数据集的相关数据已开放申请获取。