Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis

<b>Background</b>: The aim of the meta-analysis was to evaluate the association between 10 widely studied polymorphisms of interleukin-23 receptor gene (<i>IL-23R</i>) and ankylosing spondylitis (AS). <b>Methods</b>: A comprehensive literature search, screening of eligible articles and data extraction was performed independently by two investigators. Further meta-analysis was conducted with STATA 12.0 software (Stata Corp.; College Station, TX, USA). The association between <i>IL-23R</i> polymorphisms and AS was evaluated by odds ratio (OR) and 95% confidence intervals (95% CI). <b>Results</b>: Twenty-five case–control studies with 8431 cases and 8972 controls were included in this meta-analysis. Quantitative meta-analysis revealed that minor allele frequency (MAF) of rs1004819, rs1495965, and rs2201841 was significantly higher in the AS group (<i>p</i> value &lt; .001, &lt; .001, = .010, respectively). MAF of rs10489629, rs11209026, rs11465804, and rs1343151was significantly lower in the AS group (<i>p</i> value = .002, &lt; .001, = .032, &lt; .001, respectively). However, there is no significant difference between these two groups in rs10889677, rs11209032, and rs7517847 frequency (<i>p</i> value = .128, .237, .131, respectively). <b>Conclusions</b>: The present study indicates that minor allele carriers of rs1004819, rs1495965, and rs2201841 are susceptible to AS. Conversely, minor alleles of rs10489629, rs11209026, rs11465804, and rs1343151 have protective effect on AS.

<b>背景</b>：本元分析旨在评估白细胞介素-23受体基因（interleukin-23 receptor gene, IL-23R）的10种广泛研究的多态性与强直性脊柱炎（ankylosing spondylitis, AS）之间的关联。<b>方法</b>：由两名研究者独立完成全面的文献检索、合格文献筛选及数据提取工作。采用STATA 12.0软件（Stata公司；美国德克萨斯州学院站）进行后续元分析。通过比值比（odds ratio, OR）及95%置信区间（95% confidence intervals, 95% CI）评估IL-23R基因多态性与强直性脊柱炎的关联。<b>结果</b>：本元分析共纳入25项病例对照研究，涉及8431例病例及8972例对照。定量元分析结果显示，rs1004819、rs1495965及rs2201841的次要等位基因频率（minor allele frequency, MAF）在强直性脊柱炎组中显著升高（P值分别<0.001、<0.001、=0.010）。rs10489629、rs11209026、rs11465804及rs1343151的次要等位基因频率在强直性脊柱炎组中显著降低（P值分别=0.002、<0.001、=0.032、<0.001）。然而，rs10889677、rs11209032及rs7517847的等位基因频率在两组间无显著差异（P值分别=0.128、0.237、0.131）。<b>结论</b>：本研究表明，rs1004819、rs1495965及rs2201841的次要等位基因携带者罹患强直性脊柱炎的风险更高。相反，rs10489629、rs11209026、rs11465804及rs1343151的次要等位基因对强直性脊柱炎具有保护作用。