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Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor

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Protein Data Bank Japan2023-11-01 更新2026-03-21 收录
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Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile, PHOSPHATE ION, ... Authors: Leone, R, Cancian, L, Luciani, R, Ferrari, S, Costi, M.P, Mangani, S. Deposit date: 2007-12-15 Release date: 2008-12-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54, 2011
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2007-12-15
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