Size Does Matter. Sterically Demanding Metallocene-Substituted 3-Methylidene-Oxindoles Exhibit Poor Kinase Inhibitory Action
收藏Figshare2016-02-23 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Size_Does_Matter_Sterically_Demanding_Metallocene_Substituted_3_Methylidene_Oxindoles_Exhibit_Poor_Kinase_Inhibitory_Action/2643100
下载链接
链接失效反馈官方服务：
资源简介：
1,3-Dihydro-2H-indol-2-one (1) undergoes microwave-mediated Knoevenagel condensations with 1,2,3,4,5-pentaphenylferrocene carboxaldehyde (2b) or (η4-tetraphenylcyclobutadiene)(η5-cyclopentadienylcarboxaldehyde)cobalt (2c) to afford metallocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-one 4 or 5, respectively, in excellent yields as separable E,Z-stereoisomeric mixtures. Both 4 and 5 exhibited poor kinase inhibition and no appreciable cytotoxicity toward a leukemia cell line, attributed to the steric bulk of the metallocene substituents.
创建时间：
2016-02-23
