CONCURRENT TRAINING AND TAURINE IMPROVE LIPID PROFILE IN POSTMENOPAUSAL WOMEN

ABSTRACT Introduction: Taurine plays an important role in metabolism and can positively influence body composition, since it is believed that in appropriate concentrations this amino acid (AA) can reduce perceived exertion, thereby delaying the onset of fatigue; however, the effect of this AA combined with concurrent training in postmenopausal women is unknown. Objective: To analyze the effects of concurrent training (aerobic+resistance) and taurine supplementation on the metabolic profile of postmenopausal women. Methods: Forty-three postmenopausal women were randomly divided into the following groups: Control (C [N=13]), Taurine (T [N = 8]), Taurine+Exercise (TE [N=13]), and Placebo+Exercise (E [N=9]). The supplemented groups received capsules corresponding to a daily taurine intake of 1.5 g. Concurrent training (CT) took place three times a week and consisted of 50 minutes of resistance training and 30 minutes of aerobic training. Body composition was assessed using DXA, in addition to biochemical profile analysis: triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. The intervention period lasted for eight weeks. Statistical significance was set at 5%. Results: The TE group presented a statistical reduction in terms of relative change in the percentage of total body fat (%) (−4.1±3.0) and trunk fat (%) (−4.4±3.9), with greater lean body mass (kg) gain (3.9±2.5) when compared to groups C (0.3±3.7, p=0.005; 0.8±4.3, p=0.024; −1.1±3.1, p<0.001; respectively) and T (1.2±3.4, p=0.004; 1.6±5.4, p=0.023; −1.2±2.9; p=0.002; respectively). The TE group presented a greater percentage reduction of total cholesterol (−5.8±7.1 mg/dl) when compared to group T (11.5±19.1 mg/dl). The TE group presented a significant decrease in LDL-c (−13.6±9.2 mg/dl) compared to groups C (3.5±13.9 mg/dl, p=0.014) and T (9.9±24.3 mg/dl, p=0.027). Conclusion: The combination of concurrent training and taurine supplementation promoted a reduction in total cholesterol and LDL-c levels in postmenopausal women. Level of Evidence I; Study type: Randomized clinical study.

摘要
引言：牛磺酸（Taurine）在代谢过程中发挥关键作用，可对身体成分产生积极影响。现有研究表明，在适宜浓度下，该氨基酸（Amino Acid, AA）能够降低自觉劳累程度，进而延缓疲劳发作；但目前该氨基酸联合联合训练（Concurrent Training）对绝经后女性的影响尚未明确。
研究目的：分析联合训练（有氧训练+抗阻训练）联合牛磺酸补充剂对绝经后女性代谢指标的影响。
研究方法：将43名绝经后女性随机分为四组：对照组（C组，n=13）、牛磺酸组（T组，n=8）、牛磺酸+训练组（TE组，n=13）以及安慰剂+训练组（E组，n=9）。补充剂组每日服用剂量等效于1.5g牛磺酸的胶囊。联合训练（CT）每周开展3次，包含50分钟抗阻训练与30分钟有氧训练。采用双能X线吸收法（DXA）评估身体成分，并开展生化指标检测：甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇。干预周期为8周，统计学显著性阈值设定为5%。
研究结果：与对照组（C组：体脂百分比相对变化0.3±3.7，p=0.005；躯干脂肪百分比相对变化0.8±4.3，p=0.024；瘦体重变化-1.1±3.1，p<0.001）及牛磺酸组（T组：体脂百分比相对变化1.2±3.4，p=0.004；躯干脂肪百分比相对变化1.6±5.4，p=0.023；瘦体重变化-1.2±2.9，p=0.002）相比，TE组的总体脂百分比（-4.1±3.0%）与躯干脂肪百分比（-4.4±3.9%）均出现具有统计学意义的降低，且瘦体重增幅更高（3.9±2.5）。与牛磺酸组（11.5±19.1 mg/dl）相比，TE组的总胆固醇降幅更大（-5.8±7.1 mg/dl）。与对照组（3.5±13.9 mg/dl，p=0.014）及牛磺酸组（9.9±24.3 mg/dl，p=0.027）相比，TE组的低密度脂蛋白胆固醇（LDL-c）出现显著降低（-13.6±9.2 mg/dl）。
研究结论：联合训练与牛磺酸补充剂联用可降低绝经后女性的总胆固醇与低密度脂蛋白胆固醇水平。证据等级：I级；研究类型：随机临床研究。