A single-reaction knock-out study for the AABSM.

We removed each listed reaction in turn from the AABSM and re-optimized the parameter values to get the best fit to the time-course data. For each resulting model, χ2 is the weighted sum of squared residuals, and AIC is the Akaike Information Criterion. and AIC∅ are the weighted sum of squared residuals and the AIC value for the AABSM with all reactions included. Greater values of and AIC − AIC∅ correspond to a larger decrease in the quality of the fit. The reactions are grouped with related reactions and ordered by their AIC difference from the complete AABSM for the oscillation data. See the caption of Table 1 for a discussion of AIC scale.