Relationship of databases of live births and infant deaths for analysis of congenital malformations

Abstract Objectives: to describe the prevalence of congenital malformations in live births in Recife, based on the relationship of birth and infant death data. Methods: a cross-sectional study with data from the Live Birth Information System (Sinasc) and Mortality (MIS) of residents in Recife-PE between 2013 and 2015. The deterministic linkage of deaths and live births (LB) with malformation and the prevalence rate were calculated. Results: 545 (95.1%) deaths and live births were matched. According to the Sinasc, the prevalence of congenital malformations was 10.4 per 1,000 LB. After the linkage, the rate was 12.4. Malformations of the musculoskeletal system (42.1%) among live births were high-lighted, as well as malformations of the circulatory system (35.3%) found in infant deaths. Conclusions: linkage increased the prevalence of congenital malformations in the studied cohort. This demonstrates the potential of this strategy for the monitoring of congenital malformations, which can be used to monitor infant death.

摘要 研究目的：基于出生与婴儿死亡数据的关联关系，描述巴西伯南布哥州累西腓市活产儿先天性畸形的患病率。研究方法：本研究为横断面研究，采用2013至2015年累西腓市居民的活产信息系统（Live Birth Information System, Sinasc）与死亡信息系统（MIS）数据，对合并先天性畸形的活产儿与死亡病例开展确定性关联分析，并计算畸形患病率。研究结果：共完成545例（95.1%）死亡病例与活产儿的匹配。根据活产信息系统原始数据，先天性畸形患病率为10.4/1000活产儿；经数据关联后，该患病率升至12.4。活产儿群体中以肌肉骨骼系统畸形占比最高（42.1%），而婴儿死亡病例中则以循环系统畸形最为常见（35.3%）。研究结论：数据关联策略提升了本次研究队列中先天性畸形的检出患病率，这表明该策略在先天性畸形监测中具备应用潜力，可用于婴儿死亡相关的畸形监测。