<i>LINE-1</i> and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity

We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (<i>n</i> = 40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of <i>IL-6, SERPINE1</i> and <i>CRP</i> genes was related to adiposity traits and macronutrients intake. <i>SERPINE1</i> hypermethylation was also related to some metabolic alterations. <i>CRP</i> methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.本项横断面研究（样本量n=40）分析了全局甲基化与炎症基因甲基化能否作为代谢变化的早期预测因子，以及二者与膳食的关联。全局甲基化水平升高与肥胖、胰岛素抵抗以及膳食质量降低显著相关。白细胞介素6（IL-6）、纤溶酶原激活物抑制剂1（SERPINE1）及C反应蛋白（CRP）基因的甲基化水平与肥胖表型及宏量营养素摄入存在关联。纤溶酶原激活物抑制剂1（SERPINE1）的高甲基化还与部分代谢异常相关。C反应蛋白（CRP）基因甲基化相较于血浆CRP浓度，是更为优异的胰岛素抵抗预测因子。全局甲基化与炎症基因启动子高甲基化可作为肥胖及代谢变化的优良早期生物标志物，且与膳食质量密切相关。