Mechanic Insight into the Distinct Roles of Ovariectomy Versus Adrenalectomy on Age-related Thymic atrophy in Female Mice (PRJCA043832)

Age-related thymic atrophy, a hallmark of immunosenescence linked to age-related diseases, involves gonadal and adrenal steroid hormones, but their distinct roles and mechanisms in this process remain unclear. Accordingly, we performed RNA-seq to explore the effects of ovariectomy versus adrenalectomy on thymus function in female mice.