Additional file 1 of Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions

Additional file 1: Table S1. Metadata of analysed ENCODE files. Table S2. Results from the Epigenome Wide Association Study (EWAS): 1,800 CpGs differentially methylated between the three groups of women (non-smokers, current smokers or former smokers) (p-value corrected for False Discovery Rate (FDR) <0.05). Table S3. Results from the regional analysis using comb-p : 203 Differentially Methylated Regions including 1023 CpGs. Table S4. Comparison of the number of CpGs found significantly associated with smoking between the present EDEN study and previous studies conducted on placenta and cord blood.

补充材料1：表S1。本次分析的ENCODE（Encyclopedia of DNA Elements）文件元数据。表S2：表观全基因组关联研究（Epigenome Wide Association Study, EWAS）结果：在三组女性（非吸烟者、当前吸烟者及既往吸烟者）中鉴定出1800个差异甲基化CpG位点，且经假发现率（False Discovery Rate, FDR）校正后的P值<0.05。表S3：使用comb-p进行区域分析的结果：共包含203个差异甲基化区域，涵盖1023个CpG位点。表S4：本EDEN研究与既往针对胎盘和脐带血开展的研究中，与吸烟显著相关的CpG位点数量对比。