Dental anomalies in the deciduous dentition of non-syndromic oral clefts patients

Abstract Objectives: to investigate the prevalence of dental anomalies in complete deciduous dentition of children with NSCL/P. Methods: this study included 75 children with NSCL/P and 286 healthy control. In both groups the children had deciduous dentition with ages varying from 4 to 6 years. Clinical examination, panoramic and periapical radiographies were performed and dental anomalies of number and shape were considered. Results: there was a higher prevalence of dental anomalies in the case group, compared to the control group. In all, 42 dental anomalies were identified, 25.33% in the case group and 8.04% in control group (p<0.001). Therewas a higher frequency of dental anomalies in NSCL/P (47.36%), followed by non-syndromic cleft lip (31.57%) and non-syndromic cleft palate (21.05%). The occurrence of agenesis (p= 0.005) and twinning (p = 0.029) were higher in the case group. Conclusions: the occurrence of agenesis and dental twinning was more frequent in the case group and may contribute to the definition of oral cleft subphenotype.

摘要
研究目的：探究非综合征性唇裂伴腭裂（NSCL/P）患儿完整乳牙列的牙发育异常患病率。
研究方法：本研究纳入75例NSCL/P患儿与286名健康对照儿童，两组受试儿童均为4~6岁的乳牙列期个体。对所有受试者开展口腔临床检查、全口曲面断层片与根尖片拍摄，统计分析牙齿数目异常与形态异常两类牙发育异常情况。
研究结果：病例组牙发育异常患病率显著高于对照组。共检出42例牙发育异常，病例组患病率为25.33%，对照组为8.04%（p<0.001）。非综合征性唇裂伴腭裂（NSCL/P）群体中牙发育异常发生率更高，达47.36%，其次为非综合征性单纯唇裂群体（31.57%）与非综合征性单纯腭裂群体（21.05%）。病例组中先天缺牙（agenesis）与双生牙（dental twinning）的发生率显著更高（p=0.005；p=0.029）。
研究结论：病例组先天缺牙与双生牙的发生率更高，该结果可为口腔裂隙亚表型的界定提供参考依据。