Additional file 2 of Sex specific molecular networks and key drivers of Alzheimer’s disease

Additional file 2: Supplemental Table 2. Differential expression analysis of the comparisons of various groups as the combinations of sex, disease status, and APOE genotype. Multiple tests were adjusted using the Benjamini–Hochberg’sFDR method. Genes with an FDR adjusted p value less than 0.05 and fold changegreater than 1.2 were considered significant. A) Summary of the numbers of DEGsfrom different comparisons in different brain regionsreported in 2B and 2C. B) The DEGs in the PHG of the MSBB cohort from the comparisons of sex specific and APOE genotype specific AD versus control subjects as well as disease status and APOE genotype specific males versus females. C) The DEGs in the PFC from the ROSMAP cohort from the comparisons of sex and APOE genotype specific AD versus control subjects as well as disease status and APOE genotype specific males versus females.

附加文件2：补充表2。本表格针对按性别、疾病状态与APOE基因型（APOE genotype）组合分组的多组间比较开展差异表达分析。采用Benjamini-Hochberg错误发现率（False Discovery Rate, FDR）法对多重检验进行校正。将经FDR校正的P值小于0.05且表达倍数变化（fold change）大于1.2的基因判定为差异表达显著基因。A）汇总2B与2C中报道的不同脑区多组比较所得到的差异表达基因（Differentially Expressed Genes, DEGs）数量。B）MSBB队列中海马旁回（Parahippocampal Gyrus, PHG）的DEGs，来自以下比较：性别特异性、APOE基因型特异性阿尔茨海默病（Alzheimer's disease, AD）患者与对照受试者的对比，以及疾病状态与APOE基因型特异性的男性与女性间的对比。C）ROSMAP队列中前额叶皮层（Prefrontal Cortex, PFC）的DEGs，来自以下比较：性别与APOE基因型特异性的AD患者与对照受试者的对比，以及疾病状态与APOE基因型特异性的男性与女性间的对比。