Pilot testing an ethanol cornual nerve block as a long-term analgesic for calf disbudding

Disbudding prevents horn growth in calves through thermal or chemical cauterization and causes damage that is painful for weeks following the procedure. Current pain management strategies are only effective from 1 to 2 h (local anesthetic) to 1–3 d (non-steroidal anti-inflammatory drugs). A potential practical solution for addressing longer-term pain may be to administer ethanol as a cornual nerve block. When administered at a high concentration, ethanol damages the functionality of peripheral nerves, promoting localized long-lasting analgesia. It is also thought to be painful, thus ethanol may be combined with lidocaine, as a mixed solution or administered beforehand. We tested the use of an ethanol cornual nerve block for anesthesia around the horn bud in 2 pilot studies. We used different concentrations and amounts of ethanol (100 and 70%) in combination with different ratios of lidocaine in our attempt to identify an effective block. In pilot 1, 14 non-disbudded calves were administ..., The methods are described in the associated research publication. , Please see the README associated with these data. , ---

output:
pdf\_document: default
html\_document: default
-----------------------

# Data from: Pilot testing an ethanol cornual nerve block as a long-term analgesic for calf disbudding

[Access this dataset on Dryad](https://doi.org/10.25338/B8D64S)

These materials provide additional information and context, used in this experiment, and are referenced in the corresponding publication. We describe the efficacy of an ethanol block for providing long-lasting anesthesia around the horn bud in 2 pilot studies. The first spans 5 wk and the second looks at the 24 h around the injection. In the first pilot, 14 non-disbudded female calves (n=28 horn buds) were administered 2-4 ml of 100% ethanol on each side of the head to block the cornual nerve at 3-10 d of age. The duration of loss of sensation was evaluated using pinprick tests 10 min, 1, 3, and 7 d after the block, and then weekly thereafter until 35 d or full sensation had returned. One group (number 4), received lidocaine before their...

去角术（Disbudding）通过热灼或化学烧灼的方式抑制犊牛的角生长，该操作会造成组织损伤，使犊牛在术后数周内持续承受疼痛。当前的疼痛管理策略仅能在1~2小时（局部麻醉剂（local anesthetic））至1~3天（非甾体抗炎药（non-steroidal anti-inflammatory drugs））内发挥效用。一种有望解决长期疼痛问题的实用方案，是将乙醇用于角神经阻滞（cornual nerve block）。当以高浓度给药时，乙醇可损伤外周神经功能，从而实现长效的局部镇痛。但有研究认为乙醇本身也会引发疼痛，因此可将其与利多卡因（lidocaine）混合配制为复合溶液，或提前注射利多卡因进行联合给药。我们开展了两项先导研究，测试乙醇角神经阻滞在犊牛角芽（horn bud）周围实现麻醉的效果。实验中我们设置了不同浓度与剂量的乙醇（100%与70%），并搭配不同比例的利多卡因，以期筛选出有效的阻滞方案。在第一项先导研究中，共对14头未接受去角术的犊牛实施了相关操作……相关实验方法已在关联的研究论文中详述。请参阅这些数据附带的README文件。
---
# 数据来源：乙醇角神经阻滞作为犊牛去角长效镇痛方案的先导试验
[在Dryad平台获取本数据集](https://doi.org/10.25338/B8D64S)
本数据集提供了本实验所用的补充信息与背景资料，并已在对应发表论文中被引用。我们在两项先导研究中评估了乙醇阻滞实现犊牛角芽周围长效麻醉的效果：第一项研究周期为5周，第二项研究则聚焦于注射后24小时内的观测。在第一项先导研究中，研究人员为14头未接受去角术的雌性犊牛（共28个角芽）在其3~10日龄时，于头部两侧各注射2~4毫升100%乙醇以阻滞角神经。研究人员分别于阻滞后10分钟、1天、3天、7天，以及此后每周直至第35天或犊牛完全恢复感觉时，通过针刺试验（pinprick test）评估其感觉丧失的持续时长。其中第4组犊牛在术前接受了利多卡因注射……