Transcripts with highly significant expression differences in spleen leukocytes of 2 week old NOD mice compared to two control strains.

Statistical analysis of mRNA expression data by 1-way-ANOVA (Benjamini-Hochberg, p<0.005) followed by hierarchical clustering identified 51 probe sets (representing 47 different genes) that were differentially expressed in spleen leukocytes of 2 week old NOD mice compared to two control strains (NON and C57BL/6); H, indicates 5 genes (∼11%) with significantly higher expression in NOD relative to controls; the rest, 42 (∼89%) had significantly lower expression in NOD. Fold change (FC) was calculated by ratio of means of expression in NOD mice versus controls; FC of genes of lower expression in NOD are indicated by negative values. We assigned the genes to selected functional categories based on information obtained by searches of public databases. Genes highlighted with bold font were differentially expressed at both 2 and 4 weeks.