The effects of AAV-VEGF-B and deletion of endothelial VEGFR1 on heart transcriptome in adult mice

We evaluated the effects of vascular endothelial growth factor -B (VEGF-B) and the deletion of its receptor VEGFR1 from endothelial cells on cardiac hypertrophy. Whole-genome transcriptomic analysis showed that overexpression of the ligand had similar effects on the heart transcriptome as deletion of its receptor. Both treatments also induced angiogenesis and mild cardiac hypertrophy. The aim of the study was to identify pathways, which mediate angiogenesis-induced cardiac hypertrophy. 3 wt mice treated with AAV-Scramble, 3 EC-specific VEGFR1 deleted mice with AAV-Scramble, 2 wt mice treated with AAV-VEGF-B, 4 EC-specific VEGFR1 deleted mice treated with AAV-VEGF-B