Application of iGUIDE to identify potential off-target cleavage caused by Cas9/PD1 sgRNA
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https://www.ncbi.nlm.nih.gov/sra/SRP342226
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资源简介：
We successfully develop a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPRCas9. In the adoptive therapy for relapsedrefractory aggressive B-cell non-Hodgkin lymphoma, we observed durable responses without serious adverse events and complete remission in patients treated with these PD1 knockout CAR T cells. Here we applied iGUIDE to identify potential off-target cleavage caused by Cas9/PD1 sgRNA.
创建时间：
2022-09-09
