Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

We combine transient stem cell rejuvenation with targeted removal of senescent cells to test the hypothesis that simultaneously targeting both cell-fate based aging mechanisms will maximize life and health span benefits. Drosophila midgut RNA profiles of tubGal80ts > UAS-TdTomato (WT), armGal4; tubGal80ts > UAS-OKSM (OKSM), armGal4; tubGal80ts > UAS-Sen (Sen) and armGal4; tubGal80ts > UAS-Sen; UAS-OKSM (Sen_OKSM); tubGal80ts > UAS-TdTomato (WT), esgGal4; tubGal80ts > UAS-OKSM (OKSM), esgGal4; tubGal80ts > UAS-Sen (Sen) and esgGal4; tubGal80ts > UAS-Sen; UAS-OKSM (Sen_OKSM) Updates: [Sept. 20, 2022] The GSM6058923 and GSM6058926 metadata were swapped in accordance with the sample identities. The associated data files did not change but were renamed accordingly.