ITABAG: 3D structures of macromolecules related to human health

The ITABAG includes structural biologists from Universities, National Research Council and Hospital research centres in Italy. The laboratories apply various diffraction methods to study the structure-function relationships in various macromolecules. A unifying factor for the vast majority of the macromolecules under study is that they are related to human health, either directly, being human proteins involved in some disease, or indirectly, as proteins expressed by human pathogens and validated as potential pharmacological targets. Other projects investigate basic chemical processes, such as crystal growth and polymer association and formation of nanostructures.

ITABAG数据集汇聚了来自意大利各大学、国家研究委员会以及医院研究中心的结构生物学家。这些实验室运用多种衍射方法，研究各类大分子（macromolecules）的结构-功能关联。绝大多数所研究的大分子均具备一个共同特征：它们与人类健康密切相关——既可以是直接相关，即作为参与某种疾病进程的人类蛋白质；也可以是间接相关，即作为由人类病原体表达、并被验证为潜在药理学靶点的蛋白质。另有部分项目聚焦基础化学过程，例如晶体生长、聚合物缔合以及纳米结构的形成。