Crystal structure of SARS-CoV-2 3CL protease (3CLpro) as a covalent complex with EDP-235
收藏Protein Data Bank Japan2024-11-13 更新2026-04-11 收录
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Crystal structure of SARS-CoV-2 3CL protease (3CLpro) as a covalent complex with EDP-235 Descriptor: 3C-like proteinase nsp5, 4,6,7-trifluoro-N-{(2S)-1-[(3R,5'R)-5'-(iminomethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1'-yl]-4-methyl-1-oxopentan-2-yl}-N-methyl-1H-indole-2-carboxamide, THIOCYANATE ION Authors: Cade, I.A, Rhodin, M.H.J. Deposit date: 2023-12-15 Release date: 2024-08-14 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.002 Å) Cite: The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo. Nat Commun, 15, 2024
创建时间：
2023-12-15
