ELF4 is a transcription factor, and to identify its potential targets, the inflamed colons of wild type and Elf4 deficient mice were subjected to whole genome RNA sequencing. wild type and Elf4-/- mic
This project compares colonic epithelial cells from intestinal epithelial-specific IPMK knockout and control mice upon DSS-induced acute colitis. (WT=3, KO=3)
In colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. I
Objectives: To improve understanding of the preclinical stage of colonic inflammation by exploring the existence of a link between early inflammatory changes in the colonic mucosa and the syste