FigShare neuroimaging dataset Sarabdjitsingh 2017.xlsx

<br>We exposed rats to 24 hours of maternal deprivation (MD) at postnatal day 3. Using structural magnetic resonance imaging we examined: i) volumetric changes and white/grey matter properties of the whole cerebrum and of specific brain areas; and ii) whether potential alterations could be normalized by blocking glucocorticoid receptors with mifepristone during postnatal days 26 and 28. The results show that MD caused a volumetric reduction of the prefrontal cortex, particularly the ventromedial part, and the orbitofrontal cortex. Within the whole cerebrum, white (relative to grey) matter volume was decreased and region-specifically in prefrontal cortex and dorsomedial striatum following MD. A trend was found for the hippocampus. Grey matter fractions were not affected. Treatment with mifepristone did not normalize these changes.

本研究于大鼠出生后第3天，对其实施24小时的母本剥夺（maternal deprivation, MD）造模。采用结构磁共振成像（structural magnetic resonance imaging）开展检测，具体涵盖两项内容：① 全大脑及特定脑区的体积变化与白质、灰质特性；② 在出生后第26天至第28天期间，通过米非司酮（mifepristone）阻断糖皮质激素受体后，是否可使潜在的脑结构异常改变恢复正常。结果显示，母本剥夺会导致前额叶皮层（尤其是其腹内侧亚区）与眶额叶皮层的体积缩小。全大脑范围内，白质（相较于灰质）体积出现降低，且该变化在MD造模后的前额叶皮层与背内侧纹状体中呈现脑区特异性；海马体则呈现出变化趋势。灰质占比未受显著影响。米非司酮干预并未使上述改变恢复至正常水平。