Gene expression changes in white blood cells of hypertensive patients with left ventricular remodeling

Using transcriptomic we looked for changes in large-scale gene expression profiling of leukocytes of hypertensive patients with left ventricular remodeling compared to hypertensive patients without left ventricular remodeling and to control and whether these changes reflect metabolic pathway regulation already shown by positron emission tomography. Genes encoding for glycolytic enzymes were found over-expressed in the group of hypertensive patients with left ventricular remodeling. Expression of master genes involved in fatty acids β-oxidation was unchanged. Transcriptomic analysis included 14 patients with hypertension and left ventricular hypertrophy, 14 patients with hypertension and normal left ventricular size and 8 control individuals.