New metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: Synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities
收藏Taylor & Francis Group2016-08-26 更新2026-04-16 收录
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Four new neutral diclofenac-based complexes, [Co(dicl)<sub>2</sub>(2-pyet)<sub>2</sub>] <b>1</b>, [Ni(dicl)<sub>2</sub>(2-pyet)<sub>2</sub>] <b>2,</b> [Cu<sub>2</sub>(dicl)<sub>2</sub>(2-pyet)<sub>2</sub>] <b>3</b> and [Cu<sub>2</sub>(dicl)<sub>2</sub>(2-pypr)<sub>2</sub>] <b>4</b> have been synthesized and characterized by elemental analysis, FT-IR, thermal analysis. Complexes <b>1</b>, <b>3</b> and <b>4</b> have also been characterized by X-ray single crystal structural analysis. The compounds of Co(II) and Ni(II) have octahedral geometry with two diclofenac and two 2-pyridineethanol ligands in the coordination sphere. The compounds of Cu(II) have square-pyramidal geometry and Cu(II) ions are linked via oxygens to the bridging 2-pyridineethanol or 2-pyridinepropanol ligands. The Δ<i>ν</i> values acquired by FT-IR are in agreement with the single XRD data. Studies on the thermal properties are reported and the complexes are stable to 196, 216, 215 and 201°C in air, respectively. Two dinuclear Cu(II) complexes have demonstrated catalytic activity on oxidation of 3,5-di-<i>tert-</i>butylcatechol to 3,5-di-<i>tert</i>-butylquinone showing saturation kinetics at high substrate concentrations. The diclofenac complexes are investigated as inhibitors of the human cytosolic isoforms hCA I and II. The complexes are good as hCA I inhibitors (K<sub>i</sub>s of 1.52-55.06 μM) but only moderately efficient as hCA II inhibitors (K<sub>i</sub>s of 0.23-5.61 μM).
提供机构：
Bulent Caglar
创建时间：
2016-08-26
