Callus Analog Framework

Utilizing the MASON simulation toolkit, this framework implements four mechanisms which aim to describe the fracture healing process. Our in silico Callus Analogs attempt to simulate the transition of the histologic appearance of a mouse fracture callus from day-7 to day-10 of the healing process. After applying rigorous cycles of the Iterative Refinement Protocol, our mechanisms achieved 73-94% similarity when compared to the prespecified histologic appearance of the fracture callus at day-10. Simulated healing provides a new perspective on the actual healing process and a new way of thinking about plausible networked fracture healing processes. This work is intended to be applicable to other biomedical fields that use histologic analysis to investigate and explain tissue level phenomena.Researchers may choose between the four implemented mechanisms through the GUI, and may extend this initial work with customized mechanisms and additional tissue units. Installation instructions are provided in a README file bundled with the source code. <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=1319#pack_1944">Callus </a> </li> </ul>

运用 MASON 模拟工具包，本框架实现了四种机制，旨在描述骨折愈合过程。我们的虚拟瘢痕模拟试图模拟小鼠骨折瘢痕在愈合过程中从第7天至第10天的组织学形态变化。经过严谨的迭代优化协议循环应用后，我们的机制在与预先设定的第10天骨折瘢痕组织学形态对比时，达到了73-94%的相似度。模拟愈合过程为实际愈合过程提供了新的视角，并开辟了关于可能的网络化骨折愈合过程的思考新路径。本研究旨在适用于其他使用组织学分析来研究和解释组织层面现象的生物医学领域。研究人员可通过图形用户界面选择四种实现的机制，并可通过定制机制和额外组织单元扩展这一初步工作。安装说明包含在源代码附带的 README 文件中。

本项目包含以下软件/数据包：

<ul>
<li><a href="https://simtk.org/frs?group_id=1319#pack_1944">Callus</a></li>
</ul>