Figure 4 Raw imageJ data

<b>Figure 4. Nine proteins relevant to inflammation, transcription regulation and metabolism are significantly increased in post-mortem autopsy brains of human sporadic Alzheimer’s disease. a-b. </b>Western blot and quantifications showing significantly elevated levels of predicted proteins relevant to inflammatory pathways (PIBF1, CRTAM, FRRS1, and LILRA3), transcriptional regulation (FOXP4 and SPOP), metabolism (PIBF1 and STARD3), and others (TXNDC12 and FAM92B) in post-mortem temporal cortical samples of sporadic AD compared to age-matched healthy controls (HC). Note that SCGB3A1 and SLC44A2 were not detectable. Data shown are mean + s.e.m; two-tailed <i>t </i>tests Welch-corrected; *p&lt;0.05; **p&lt;0.01, (P values for FRRS1 = 0.0340, STARD3 = 0.0176, PIBF1 = 0.0363, TXNDC12 = 0.0122, FAM92B = 0.0456, FOXP4 = 0.0474, SPOP = 0.0183, CRTAM = &lt;0.0001, and LILRA3 = 0.0392) n=7 healthy controls and n=8 sporadic AD).<b></b>

**图4. 9种与炎症、转录调控及代谢相关的蛋白质在人类散发性阿尔茨海默病（sporadic Alzheimer’s disease, AD）患者死后尸检脑组织中表达显著上调。a-b。**蛋白质免疫印迹（Western blot）实验及其定量分析结果显示，与年龄匹配的健康对照（healthy controls, HC）相比，散发性AD患者死后颞叶皮层样本中，与炎症通路相关的预测蛋白（PIBF1、CRTAM、FRRS1及LILRA3）、转录调控相关蛋白（FOXP4与SPOP）、代谢相关蛋白（PIBF1与STARD3）及其他蛋白（TXNDC12与FAM92B）的表达水平均显著升高。需注意，SCGB3A1与SLC44A2未被检测到。本图数据以平均值±标准误（mean ± s.e.m.）呈现；采用Welch校正的双尾t检验进行统计分析；*p<0.05，**p<0.01（各蛋白的P值分别为：FRRS1=0.0340，STARD3=0.0176，PIBF1=0.0363，TXNDC12=0.0122，FAM92B=0.0456，FOXP4=0.0474，SPOP=0.0183，CRTAM<0.0001，LILRA3=0.0392）；健康对照样本量n=7，散发性AD患者样本量n=8）。