HA and DIR's

This study aims to investigate the underlying mechanisms and triggers of delayed-onset inflammatory responses DIRs after hyaluronic acid (HA) fillers injections. The literature review included articles on DIRs following HA filler treatments and identified immunological triggers, bacterial contamination, and filler degradation as key factors contributing to DIRs. Additionally, patient data were analyzed from patients treated for DIRs and showed possible immune activation events prior to DIRs included flu-like symptoms. This study underscores the complexity of DIRs following HA filler treatments and the need for transparency from manufacturers. Comprehensive ingredient data are crucial to better understand DIRs and ensure patient safety.

本研究旨在探究透明质酸（hyaluronic acid, HA）填充剂注射后迟发性炎症反应（delayed-onset inflammatory responses, DIRs）的潜在发病机制与诱发因素。本研究通过文献综述纳入了HA填充剂治疗后发生DIRs的相关文献，并明确了免疫触发因素、细菌污染及填充剂降解是导致DIRs的关键致病因素。此外，本研究对因DIRs接受诊疗的患者数据进行分析，结果显示，DIRs发作前可能存在类流感症状等免疫激活事件。本研究凸显了HA填充剂治疗后DIRs发生的复杂性，同时强调了生产厂商需提升信息透明度的必要性。全面的成分数据对于深入解析DIRs的发生机制、保障患者安全具有至关重要的意义。